GUANÁBANA

ACABO HOY DE RECIBIR UNA LLAMADA DE UNA QUÍMICA DE LA UNIVERSIDAD DE HUMACAO,QUE ME GARANTIZÓ ,QUE VERDADERAMENTE  LOS GUÁRAPOS DE ESTEA PLANTA SON ANTITUMÓRICAS.ES BUENA PARA EL CANCER.COSA RARA,EN MIS TIEMPOS SUS HOJAS ALEJABAN LAS CUCARACHAS.5 DE MAYO 2018  RECUERDE TIENE QUE TENER CUIDADO AL USARLA.LEA ESTE ARTÍCULO

 Annona muricata L. (Magnoliales: Annonaceae) is a tropical plant species known for its edible fruit which has some medicinal merits, but also some toxicological effects. This review focuses on the phytochemicals contents, bioactivity, biological actions and toxicological aspects of extracts and isolated compounds, as well as medicinal uses of A. muricata, with the objective of stimulating further studies on extracts and fruit pulp used for human consumption. Traditional medicinal uses of A. muricata have been identified in tropical regions to treat diverse ailments such as fever, pain, respiratory and skin illness, internal and external parasites, bacterial infections, hypertension, inflammation, diabetes and cancer. More than 200 chemical compounds have been identified and isolated from this plant; the most important being alkaloids, phenols and acetogenins. Using in vitro studies, extracts and phytochemicals of A. muricata have been characterized as an antimicrobial, anti-inflammatory, anti-protozoan, antioxidant, insecticide, larvicide, and cytotoxic to tumor cells. In vivo studies of the crude extracts and isolated compounds of A. muricata were shown to possess anxiolytic, anti-stress, anti-inflammatory, contraceptive, anti-tumoral, antiulceric, wound healing, hepato-protective, anti-icteric and hypoglycemic activities. In addition, clinical studies support the hypoglycemic activity of the ethanolic extracts of A. muricata leaves. Mechanisms of action of some pharmacological activities have been elucidated, such as cytotoxic, antioxidant, antimicrobial, antinociception and hypotensive activities. However, some phytochemical compounds isolated from A. muricata have shown a neurotoxic effect in vitro and in vivo, and therefore, these crude extracts and isolated compounds need to be further investigated to define the magnitude of the effects, optimal dosage, mechanisms of action, long-term safety, and potential side effects. Additionally, clinical studies are necessary to support the therapeutic potent

 Natural products, especially those derived from plants, have been used to help mankind sustain its health since the dawn of medicine. Over the past century, the phytochemicals in plants have been a pivotal pipeline for pharmaceutical discovery. The importance of the active ingredients of plants in agriculture and medicine has stimulated significant scientific interest in the biological activities of these substances [1]. Despite these studies, a restricted range of plant species has experienced detailed scientific inspection, and our knowledge is comparatively insufficient concerning their potential role in nature. Hence, the attainment of a reasonable perception of natural products necessitates comprehensive investigations on the biological activities of these plants and their key phytochemicals [2]. In a pharmaceutical landscape, plants with a long history of use in ethno medicine are a rich source of active phytoconstituents that provide medicinal or health benefits against various ailments and diseases. One such plant with extensive traditional use is Annona muricata. In this review, we describe the botany, distribution and ethnomedicinal uses of this plant, and we summarize the phytochemistry, biological activities and possible mechanisms of A. muricata bioactivities.